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The compounds safety and pharmacological profile have been comprehensively assessed in rodent models.In preclinical trials, including those involving ovariectomized (OVX) rat models, both low- and high-dose AOD-9604 regimens showed no significant toxicity

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Medical professionals actually classify this excess abdominal skin into different grades based on severity: Grade 1 : A mild overhang just covering the pubic area Grade 2 : Extends enough to cover the genital region Grade 3 : Reaches down to the upper thigh Grade 4 : Extends to mid-thigh level Grade 5 : Reaches the knees or even lower Whats important to understand is that a pannus consists mainly of skin and subcutaneous fat